Pyronaridine tetraphosphate

Research use only, not for human use.

Pyronaridine tetraphosphate is an orally active, mannitol-containing inhibitor of DNA topoisomerase 2 and erythrocyte cytokine with antimalarial and antitumour activity.

Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection.

Pyronaridine tetraphosphate (24 h) shows anti-P. falciparum activity with an IC50 value of 1.53-3.94 nM.Cell Viability Assay Cell Line:P. falciparum: 3D7, K1, VS1, FCB, TM90C2a, FCR3 Concentration:0-7 nM approximately Incubation Time:24 h Result:Exhibited anti-P. falciparum activity with Mean IC50 values of 2.31 nM, 3.94 nM, 1.63 nM, 1.53 nM, 2.51 nM, 2.21 nM repectively.

Pyronaridine (57 mg/kg, oral administration, q.d. for 30 days) tetraphosphate reduces the parasitic burden in the Echinococcus granulosus-infected mice.Pyronaridine (57 mg/kg, intraperitoneal injection, q.d. for 3 days) tetraphosphate reduces the parasitic burden in secondarily infected (cysts) mice.Pyronaridine (57 mg/kg, intraperitoneal injection, for a single dose) tetraphosphate exhibits a higher exposure in the liver than in the plasma in male ICR mice.Animal Model:Echinococcus granulosus-infected mice model Dosage:57 mg/kg Administration:Oral administration, q.d. for 30 days Result:Reduced 42.4% of parasite wet weight and killed 90.7% of secondary infection (cysts) of E. granulosus ss.

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Cell Cycle/DNA Damage

Topoisomerase

Topoisomerase

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76748-86-2

910.03

C29H44ClN5O18P4

>98% (HPLC)

In Vitro:?H2O : 25 mg/mL (27.47 mM; Ultrasonic (<60°C)) DMSO : 12.5 mg/mL (13.74 mM; Ultrasonic (<60°C)

O=P(O)(O)O.ClC(C=CC1=C2NC3=CC(CN4CCCC4)=C(O)C(CN5CCCC5)=C3)=CC1=NC6=C2N=C(OC)C=C6.O=P(O)(O)O.O=P(O)(O)O.O=P(O)(O)O

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(-20℃)

With Ice Pack

≥ 2 years